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KMID : 0931320020020010018
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대한상부위장관.헬리코박터학회지
2002 Volume.2 No. 1 p.18 ~ p.24
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Association between Helicobacter pylori Infection and the Risk of Gastric Cancer Among the Korean People: Prospective Case-controlled Study
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Chang Woong-Ki
Kim Hak-Yang
Kim Yong-Bum
Kim Dong-Joon
Lee Jin
Park Choong-Kee
Yoo Jae-Young
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Abstract
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Background/Aims: We conducted a propective case-controlled study matched and adjusted by age, sex, education and economic status to evaluate the causal relationship between H.pylori infection and gastric cancer among Korean people.
Methods: From March 1997 to October 1998, consecutive 136 gastric cancer patients diagnosed by endoscopic histology and 136 age and sex matched control subjects confirmed to be free gastric cancer by endosocpy during the same period were selected. The presence of H.pylori ingection was determined by EIA serology test.
Results: Seventy-two patients(53%) of the 136 gastric cancer patients were positive for H.pylori infection and 54(40%) of the136 control subjects were positive for H.pylori infection . The odds ratio(OR) adjusted by variable risk factors such as age, sex, education and economic status for gastric cancer in H.pylori infected patients was 1.82(95% CI, 1.1.~3.00, P=0.019). And age and sex matched OR by conditional logistic regression was 1.6(95% CI, 1.01~2.53, P=0.043).
Conclusions: H.pylori infection might be one of the important rick factors for the development of gastric cancer in Korea, the area of high prevalence of H.pylori infection and high incidence rate of gastric cancer.
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KEYWORD
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Gastric cancer, Helicobacter pylori
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